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Post-translational regulation of lipogenesis via AMPK-dependent phosphorylation of insulin-induced gene

found that 7-isopentenoxycoumarin significantly induced melanogenesis at a dose of 40 m, with the highest induction of melanin at 72 h, and excitingly the induction was 6-fold greater than that of the control group, and the mechanism of action was to increase melanogenesis by elevating MITF and its downstream genes tyrosinases, TRP-1 and Trp-2

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Zhang Y, Tan L, Li C, Wu H, Ran D, Zhang Z